abstract：INTRODUCTION:Malaria is the largest cause of health services attendance, hospital admissions and child deaths in Tanzania. At the Abuja Summit in April 2000 Tanzania committed itself to protect 60% of its population at high risk of malaria by 2005. The country is, therefore, determined to ensure that sustainable malari...

journal_title：Malaria journal

authors： Magesa SM,Lengeler C,deSavigny D,Miller JE,Njau RJ,Kramer K,Kitua A,Mwita A

更新日期：2005-07-22 00:00:00

abstract：BACKGROUND:In children with malaria caused by Plasmodium falciparum, quinine administered rectally may be easier to use and less painful than intramuscular or intravenous administration. The objective of this review was to compare the effectiveness of intrarectal with intravenous or intramuscular quinine for treating f...

journal_title：Malaria journal

authors： Eisenhut M,Omari A,MacLehose HG

更新日期：2005-05-18 00:00:00

abstract：:The general paradigm that emerges from the analysis of the transcriptome of the malaria parasite Plasmodium falciparum is that the expression clusters of genes that code for enzymes engaged in the same cellular function is coordinated. Here the consistency of this perception is examined by analysing specific pathways ...

journal_title：Malaria journal

authors： Bozdech Z,Ginsburg H

更新日期：2005-03-18 00:00:00

abstract：BACKGROUND:P25 and P28 are related ookinete surface proteins highly conserved throughout the Plasmodium genus that are under consideration as candidates for inclusion in transmission-blocking vaccines. Previous research using transgenic rodent malaria parasites lacking P25 and P28 has demonstrated that these proteins h...

journal_title：Malaria journal

authors： Baton LA,Ranford-Cartwright LC

更新日期：2005-02-25 00:00:00

abstract：BACKGROUND:Polyclonal B-cell activation is well known to occur in Plasmodium infections, but its role in pathogenesis or protection remains unclear. However, protective properties of natural antibodies have previously been demonstrated in other contexts. METHODS:Sera from asymptomatic and symptomatic Plasmodium-infect...

journal_title：Malaria journal

authors： Fesel C,Goulart LF,Silva Neto A,Coelho A,Fontes CJ,Braga EM,Vaz NM

更新日期：2005-01-20 00:00:00

abstract：BACKGROUND:It was unknown whether the main reservoir of Plasmodium falciparum and Plasmodium vivax, which infects mosquitoes in Thailand, was (a) in people feeling sufficiently ill with malaria to come to a clinic or (b) in people who had remained in their home villages with some fever symptoms or with none. METHODS:M...

journal_title：Malaria journal

authors： Pethleart A,Prajakwong S,Suwonkerd W,Corthong B,Webber R,Curtis C

更新日期：2004-09-22 00:00:00

abstract：BACKGROUND:The relationship between the burden of uncomplicated malaria and transmission intensity is unclear and a better understanding of this relationship is important for the implementation of intervention programmes. METHODS:A 6-month longitudinal study monitoring risk factors for anaemia and febrile malaria epis...

journal_title：Malaria journal

authors： Lusingu JP,Vestergaard LS,Mmbando BP,Drakeley CJ,Jones C,Akida J,Savaeli ZX,Kitua AY,Lemnge MM,Theander TG

更新日期：2004-07-28 00:00:00

abstract：:The classic formulae in malaria epidemiology are reviewed that relate entomological parameters to malaria transmission, including mosquito survivorship and age-at-infection, the stability index (S), the human blood index (HBI), proportion of infected mosquitoes, the sporozoite rate, the entomological inoculation rate ...

journal_title：Malaria journal

authors： Smith DL,McKenzie FE

更新日期：2004-06-04 00:00:00

abstract：BACKGROUND:Arthropod vectors of disease may encounter more than one infected host during the course of their lifetime. The consequences of super-infection to parasite development are rarely investigated, but may have substantial epidemiological and evolutionary consequences. METHODS:Using a rodent malaria model system...

journal_title：Malaria journal

authors： Ferguson HM,Read AF

更新日期：2004-05-19 00:00:00

abstract：BACKGROUND:Surveillance for drug-resistant Plasmodium falciparum should be a component of malaria control programmes. Real-time PCR methods for the detection of parasite single-nucleotide polymorphisms (SNPs) and gene amplification could be useful survellance tools. METHODS:A real-time PCR assay has been developed tha...

journal_title：Malaria journal

authors： Purfield A,Nelson A,Laoboonchai A,Congpuong K,McDaniel P,Miller RS,Welch K,Wongsrichanalai C,Meshnick SR

更新日期：2004-05-07 00:00:00

abstract：BACKGROUND:Isolation of a concentrated, living preparation of malarial parasite-infected red blood cells (PRBCs) that have low contamination of white blood cells (WBCs) facilitates research on the molecular, biochemical and immunological aspects of malarial parasites. This is currently carried out by a two-step method,...

journal_title：Malaria journal

authors： Trang DT,Huy NT,Kariu T,Tajima K,Kamei K

更新日期：2004-03-17 00:00:00

abstract：:BACKGROUND: Removal of exhaled air from total body emanations or artificially standardising carbon dioxide (CO2) outputs has previously been shown to eliminate differential attractiveness of humans to certain blackfly (Simuliidae) and mosquito (Culicidae) species. Whether or not breath contributes to between-person di...

journal_title：Malaria journal

authors： Mukabana WR,Takken W,Killeen GF,Knols BG

更新日期：2004-01-29 00:00:00

abstract：:BACKGROUND: The development of Plasmodium falciparum within human erythrocytes induces a wide array of changes in the ultrastructure, function and antigenic properties of the host cell. Numerous proteins encoded by the parasite have been shown to interact with the erythrocyte membrane. The identification of new intera...

journal_title：Malaria journal

authors： Lauterbach SB,Lanzillotti R,Coetzer TL

更新日期：2003-12-17 00:00:00

abstract：:BACKGROUND: This study investigated causes of malaria and how cases were managed at household level, in order to improve the ability to identify malaria and ensure correct use of chloroquine. It was conducted in Nakonde District, Northern Province of Zambia, between 2000 and 2001. Nakonde district is in a hyperendemic...

journal_title：Malaria journal

authors： Kaona FA,Tuba M

更新日期：2003-11-19 00:00:00

abstract：:BACKGROUND: In areas of high-level, year-round malaria transmission, morbidity and mortality due to malaria decrease after the first two to three years of life. This reduction may be related to the development of cellular immunity to specific antigens expressed in the different life-cycle stages of Plasmodium falcipar...

journal_title：Malaria journal

authors： Chelimo K,Sumba PO,Kazura JW,Ofula AV,John CC

更新日期：2003-11-05 00:00:00

abstract：BACKGROUND:Zooprophylaxis, the diversion of disease carrying insects from humans to animals, may reduce transmission of diseases such as malaria. However, as the number of animals increases, improved availability of blood meals may increase mosquito survival, thereby countering the impact of diverting feeds. METHODS:C...

journal_title：Malaria journal

authors： Saul A

更新日期：2003-09-19 00:00:00

abstract：BACKGROUND:Malaria is known as tazo or tazomoka in local terminology in Madagascar. Within the context of traditional practice, malaria (and/or malaria symptoms) is commonly treated by decoctions or infusions from bitter plants. One possible approach to the identification of new antimalarial drug candidates is to searc...

journal_title：Malaria journal

authors： Randrianarivelojosia M,Rasidimanana VT,Rabarison H,Cheplogoi PK,Ratsimbason M,Mulholland DA,Mauclère P

更新日期：2003-07-24 00:00:00

abstract：BACKGROUND:Malaria can be eradicated from islands. To assess the prospects for eradication of malaria from the island of Príncipe in the Gulf of Guinea, we fitted a mathematical model to age-prevalence curves and thus obtained estimates of the vectorial capacity and of the basic reproductive number (R0) for malaria. M...

journal_title：Malaria journal

authors： Hagmann R,Charlwood JD,Gil V,Ferreira C,do Rosário V,Smith TA

更新日期：2003-06-18 00:00:00

abstract：BACKGROUND:Rapid diagnosis and correct treatment of cases are the main objectives of control programs in malaria-endemic areas. METHODS AND RESULTS:To evaluate these criteria and in a comparative study, blood specimens were collected from 120 volunteers seeking care at the Malaria Health Center in Chahbahar district. ...

journal_title：Malaria journal

authors： Zakeri S,Najafabadi ST,Zare A,Djadid ND

更新日期：2002-02-08 00:00:00